Rab 5A (AB1844) Rabbit mAb
Product Specifications
Background
Enzyme regulation:Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP. , function:Required for the fusion of plasma membranes and early endosomes. , similarity:Belongs to the small GTPase superfamily. Rab family. , subcellular location:Enriched in stage I melanosomes. , subunit:Binds EEA1. Interacts with RIN1 and GAPVD1, which regulate its pathway, probably by acting as a GEF. Interacts with ALS2CL, UNC84B, ZFYVE20 and RUFY1. Interacts with SGSM1 and SGSM3.
Synonyms
RAB5A, RAB5, Ras-related protein Rab-5A
Gene Name
>>Ras signaling pathway, >>Endocytosis, >>Phagosome, >>Vasopressin-regulated water reabsorption, >>Amyotrophic lateral sclerosis, >>Pathways of neurodegeneration-multiple diseases, >>Salmonella infection, >>Amoebiasis, >>Tuberculosis
Gene ID
5868
Swiss Prot
P20339
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant protein (or fragment) . This information is considered to be commercially sensitive.
Clonality
Monoclonal
Source
Monoclonal, Rabbit, IgG
Applications
WB, IHC, IF, IP, ELISA
Purification
The antibody was purified by protein A affinity chromatography.
Dilution
WB, 1:1000-1:5000 | IHC, 1:1000-1:4000 | IF, 1:200-1:1000 | IP, 0. 5μg-4μg antibody for 200μg-400μg extracts of whole cells. | ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Modification
Unmodified
Storage Conditions
Store at-20°C. Avoid freeze / thaw cycles.
Specificity
This antibody detects endogenous levels of Rab 5A protein.
Formulation
The antibody is provided in liquid form in phosphate - buffered saline with 50% glycerol, 0.05% BSA, and 0.05% Proclin 300.
Protein Name
Rab 5A
Available Sizes
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