Rab 5A (AB1844) Rabbit mAb

Product Specifications

Background

Enzyme regulation:Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP. , function:Required for the fusion of plasma membranes and early endosomes. , similarity:Belongs to the small GTPase superfamily. Rab family. , subcellular location:Enriched in stage I melanosomes. , subunit:Binds EEA1. Interacts with RIN1 and GAPVD1, which regulate its pathway, probably by acting as a GEF. Interacts with ALS2CL, UNC84B, ZFYVE20 and RUFY1. Interacts with SGSM1 and SGSM3.

Synonyms

RAB5A, RAB5, Ras-related protein Rab-5A

Gene Name

>>Ras signaling pathway, >>Endocytosis, >>Phagosome, >>Vasopressin-regulated water reabsorption, >>Amyotrophic lateral sclerosis, >>Pathways of neurodegeneration-multiple diseases, >>Salmonella infection, >>Amoebiasis, >>Tuberculosis

Gene ID

5868

Swiss Prot

P20339

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein (or fragment) . This information is considered to be commercially sensitive.

Clonality

Monoclonal

Source

Monoclonal, Rabbit, IgG

Applications

WB, IHC, IF, IP, ELISA

Purification

The antibody was purified by protein A affinity chromatography.

Dilution

WB, 1:1000-1:5000 | IHC, 1:1000-1:4000 | IF, 1:200-1:1000 | IP, 0. 5μg-4μg antibody for 200μg-400μg extracts of whole cells. | ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.