Bad (AB1784) Rabbit mAb

The protein encoded by this gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform. [provided by RefSeq, Jul 2008]

BAD, BBC6, BCL2L8, Bcl2 antagonist of cell death, BAD, Bcl-2-binding component 6, Bcl-2-like protein 8, Bcl2-L-8, Bcl-XL/Bcl-2-associated death promoter

>>EGFR tyrosine kinase inhibitor resistance, >>Endocrine resistance, >>Platinum drug resistance, >>ErbB signaling pathway, >>Ras signaling pathway, >>cGMP-PKG signaling pathway, >>cAMP signaling pathway, >>Chemokine signaling pathway, >>Autophagy-animal, >>PI3K-Akt signaling pathway, >>Apoptosis, >>VEGF signaling pathway, >>Focal adhesion, >>Neurotrophin signaling pathway, >>Insulin signaling pathway, >>Thyroid hormone signaling pathway, >>Alzheimer disease, >>Amyotrophic lateral sclerosis, >>Prion disease, >>Pathways of neurodegeneration-multiple diseases, >>Toxoplasmosis, >>Tuberculosis, >>Hepatitis C, >>Hepatitis B, >>Measles, >>Human papillomavirus infection, >>Herpes simplex virus 1 infection, >>Human immunodeficiency virus 1 infection, >>Pathways in cancer, >>Viral carcinogenesis, >>Chemical carcinogenesis-receptor activation, >>Chemical carcinogenesis-reactive oxygen species, >>Colorectal cancer, >>Renal cell carcinoma, >>Pancreatic cancer, >>Endometrial cancer, >>Prostate cancer, >>Melanoma, >>Chronic myeloid leukemia, >>Acute myeloid leukemia, >>Non-small cell lung cancer, >>Hepatocellular carcinoma, >>Lipid and atherosclerosis

WB, 1:1000-1:5000 | IHC, 1:200-1:1000 | IF, 1:200-1:1000 | IP, 0. 5μg-4μg antibody for 200μg-400μg extracts of whole cells. | ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.