NQO1 (AB1666) Rabbit mAb

This gene is a member of the NAD (P) H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This protein&apos, s enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in this gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered expression of this protein has been seen in many tumors and is also associated with Alzheimer&apos, s disease (AD) . Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

NQO1, DIA4, NMOR1, NAD (P) H dehydrogenase [quinone] 1, Azoreductase, DT-diaphorase, DTD, Menadione reductase, NAD (P) H:quinone oxidoreductase 1, Phylloquinone reductase, Quinone reductase 1, QR1

>>Ubiquinone and other terpenoid-quinone biosynthesis, >>Metabolic pathways, >>Biosynthesis of cofactors, >>Pathways in cancer, >>Chemical carcinogenesis-reactive oxygen species, >>Hepatocellular carcinoma, >>Fluid shear stress and atherosclerosis

WB, 1:1000-1:5000 | IHC, 1:200-1:1000 | IF, 1:200-1:1000 | IP, 0. 5μg-4μg antibody for 200μg-400μg extracts of whole cells. | ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.