Mesothelin (AB1482) Rabbit mAb

Product Specifications

Background

This gene encodes a preproprotein that is proteolytically processed to generate two protein products, megakaryocyte potentiating factor and mesothelin. Megakaryocyte potentiating factor functions as a cytokine that can stimulate colony formation of bone marrow megakaryocytes. Mesothelin is a glycosylphosphatidylinositol-anchored cell-surface protein that may function as a cell adhesion protein. This protein is overexpressed in epithelial mesotheliomas, ovarian cancers and in specific squamous cell carcinomas. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]

Synonyms

Mesothelin (CAK1 antigen, Pre-pro-megakaryocyte-potentiating factor) [Cleaved into: Megakaryocyte-potentiating factor (MPF), Mesothelin, cleaved form]

Gene Name

MSLN MPF

Gene ID

10232

Swiss Prot

Q13421

Host

Rabbit

Reactivity

Human

Immunogen

A synthetic peptide corresponding to the amino acid region 400 - 500 of the human Mesothelin.

Clonality

Monoclonal

Source

Monoclonal, Rabbit, IgG

Applications

WB, IHC, ELISA

Purification

The antibody was purified by protein A affinity chromatography.

Dilution

WB, 1:500-1:2000 | IHC, 1:200-1:400 | ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.