Claudin 1 (AB1341) Rabbit mAb

Product Specifications

Background

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome. [provided by RefSeq, Jul 2008]

Synonyms

CLDN1, CLD1, SEMP1, Claudin-1, Senescence-associated epithelial membrane protein

Gene Name

CLDN1

Gene ID

9076

Swiss Prot

O95832

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

A synthetic peptide corresponding to the amino acid region 150 - 211 of the human Claudin 1.

Clonality

Monoclonal

Source

Monoclonal, Rabbit, IgG

Applications

WB, IHC, ELISA

Purification

The antibody was purified by protein A affinity chromatography.

Dilution

WB, 1:500-1:2000 | ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.

Modification

Unmodified

Storage Conditions

Store at-20°C. Avoid freeze / thaw cycles.

Specificity

This antibody detects endogenous levels of Claudin 1 (ABT184R) rabbit mAb protein.

Formulation

The antibody is provided in liquid form in phosphate - buffered saline with 50% glycerol, 0.05% BSA, and 0.05% Proclin 300.

Protein Name

Claudin 1 (ABT184R) rabbit mAb

Available Sizes

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