P53 (AB1641) Rabbit mAb
Product Specifications
Background
P53 is a tumor suppressor gene located on chromosome 17. The mutation of p53 gene will change its spatial conformation and turn into oncogene, and then lose the regulation of cell growth, apoptosis and DNA repair. The mutation or deletion of p53 gene is the cause of many tumors. Compared with the wild-type protein, the mutant p53 protein has a longer half-life, so it is easier to detect by immunohistochemistry. The p53 mutant protein is expressed in many kinds of tumors, such as breast cancer, gastrointestinal cancer, hepatocellular carcinoma and respiratory tract tumor. It is mainly used for the study of various tumors and can be used as an indicator of tumor prognosis.
Synonyms
TP53, P53, Cellular tumor antigen p53, Antigen NY-CO-13, Phosphoprotein p53, Tumor suppressor p53
Gene Name
TP53
Gene ID
7157
Swiss Prot
P04637
Host
Rabbit
Reactivity
Human, Mouse (predicted: Rat)
Immunogen
A synthetic peptide corresponding to the amino acid region 250 - 393 of the human P53 protein
Clonality
Monoclonal
Source
Monoclonal, Rabbit, IgG
Applications
WB, IHC, ELISA
Purification
The antibody was purified by protein A affinity chromatography.
Dilution
WB, 1:500-1:2000 | IHC, 1:50-1:200 | ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Modification
Unmodified
Storage Conditions
Store at-20°C. Avoid freeze / thaw cycles.
Specificity
This antibody detects endogenous levels of P53 protein.
Formulation
The antibody is provided in liquid form in phosphate - buffered saline with 50% glycerol, 0.05% BSA, and 0.05% Proclin 300.
Protein Name
P53
Available Sizes
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