CD8 a (AB1643) Rabbit mAb

Product Specifications

Background

The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain. Multiple transcript variants encoding different isoforms have been found for this gene. The major protein isoforms of this gene differ by the presence or absence of a transmembrane domain and thus differ in being a membrane-anchored or secreted protein. [provided by RefSeq, May 2020]

Synonyms

T-cell surface glycoprotein CD8 alpha chain (T-lymphocyte differentiation antigen T8/Leu-2, CD antigen CD8a)

Gene Name

CD8A MAL

Gene ID

925

Swiss Prot

P01732

Host

Rabbit

Reactivity

Mouse

Immunogen

A synthetic peptide corresponding to the amino acid region 150 - 235 of the mouse CD8 a protein

Clonality

Monoclonal

Source

Monoclonal, Rabbit, IgG

Applications

IHC, WB, ELISA

Purification

The antibody was purified by protein A affinity chromatography.

Dilution

WB, 1:500-1:2000 | IHC, 1:200-1:400 | ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.