QX-314 (bromide)

QX-314 bromide is a membrane-impermeable permanently charged sodium channel blocker[1].

Product Specifications

CAS Number

[24003-58-5]

UNSPSC

12352005

Target

Sodium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/qx-314-bromide.html

Purity

96.62

Solubility

DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 100 mg/mL (ultrasonic)

Smiles

O=C(NC1=C(C)C=CC=C1C)C[N+](CC)(CC)CC.[Br-]

Molecular Formula

C16H27BrN2O

Molecular Weight

343.30

References & Citations

[1]Rivera-Acevedo RE, et al. The quaternary lidocaine derivative, QX-314, exerts biphasic effects on transient receptor potential vanilloid subtype 1 channels in vitro. Anesthesiology. 2011 Jun;114 (6) :1425-34.|[2]Binshtok AM, et al. Coapplication of lidocaine and the permanently charged sodium channel blocker QX-314 produces a long-lasting nociceptive blockade in rodents. Anesthesiology. 2009 Jul;111 (1) :127-37.|[3]Talbot MJ, et al. Intracellular QX-314 inhibits calcium currents in hippocampal CA1 pyramidal neurons. J Neurophysiol. 1996 Sep;76 (3) :2120-4.