Anti-Human MLH1 Antibody (34077) - 100μl

MutL Homolog 1 (MLH1) is a protein involved in the mismatch-repair pathway. This protein is commonly associated with hereditary non-polyposis colorectal cancer because the MLH1 gene is frequently mutated in patients with this cancer. Studies have shown MLH1 to be deficient in a high percentage of patients with microsatellite instability as well as endometrial and ovarian cancers. Anti-MLH1 can be useful in the detection of MLH1 in a number of normal and neoplastic tissues and for identifying a loss of MLH1 in tumors that are microsatellite-unstable