Anti-Mre11 [12D7] - 100μl

Meiotic recombination 11 (Mre11), a human ortholog of Mre11A, plays an important role in repairing damaged DNA by cleaving broken ends and by providing a platform for other DNA repair proteins. During DNA double-strand break (DSB) repair, Mre11 participates in the amplification of apoptosis signaling if irreversible damage appears. Similarly, programmed DSB is required to initiate homologous recombination during the meiosis process in which MRE11 serves an essential role for DSB repair. Various Mre11 mutations have been identified in several types of cancer.