Anti-JAB-1 [Clone 8H8.5] - 100 μg

JAB-1 is a 38 kD protein which was originally described as a coactivator for cJUN. It is present in a large protein complex called the “signalosome†which has been proposed to play a signaling role in mammalian cells. This protein complex appears to be analogous to the COP9 complex in plants which plays an important role in light-mediated plant development. Although the specific function of JAB-1 is unclear, it appears to be involved in targeting proteins for degradation by the proteasome.