Anti-TSG101 Antibody (3352) - 100μl

Tumor Susceptibility Gene 101 (TSG101) codes for a 46kDa protein whose inactivation in mouse fibroblasts results in cell transformation and tumor formation in nude mice. Mutations in TSG101 have been linked to cervical, breast, prostate and gastrointestinal cancers. In addition, TSG101 is one of the cellular proteins involved in the budding process of HIV-1, and plays an important role in the cellular vacuolar protein sorting (Vps) pathway. Its main function being recognizing ubiquitinated cargo, TSG101 also proved to be essential for the budding process of HIV-1 virions.