Anti-RbAp48 [Clone 11G10] - 100 μg

RbAp48, product of the RBBP4 gene in humans, is a 48 kDa nuclear protein that was first identified through its interaction with the carboxyl-terminus of retinoblastoma protein (Rb) . In mice, the RbAp48 protein is a key component in histone acetylation, transcriptional regulation and in the cyclic adenosine monophosphate (cAMP) -protein kinase element-binding protein CREB1 path way. Since histone acetylation and the cAMP-PKA-CREB1 pathway are extremely important for normal hippocampal function, RbAp48 has been investigated to test whether decreased expression of RbAp48 in aged animals is directly associated with age-related memory loss.