Proliferating Cell Nuclear Antigen (12502P) - 25 μg
PCNA is located in the nucleus and is a cofactor of DNA polymerase delta. PCNA acts as a homotrimer and helps in processing of leading strand synthesis during DNA replication. In reaction to DNA damage, PCNA is ubiquitinated and participates in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for PCNA gene. PCNA is expressed during late G1 phase, S phase of mitosis, and persists until the end of the M phase. PCNA can be induced by UV irradiation.
Product Specifications
Target
Proliferating Cell Nuclear Antigen
Applications
WB
Concentration
Lot Specific
Shipping Conditions
Next Day 2-8°C
Storage Conditions
Although stable at 4°C for 4 weeks, product is best stored at or below -20°C. Addition of a carrier protein (such as 0.1% HSA or BSA) is recommended for long-term storage. For in vitro investigational use only.
Formulation
Sterile-filtered solution in 20mM Tris, pH 7.5, 2mM EDTA, and 20% glycerol.
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