Anti-8-oxoG DNA/RNA Oxidative Damage [Clone 15A3] - 100 μg

8-Hydroxyguanosine (8-OHG) is a critical biomarker of oxidative stress and a primary indicator of oxidative DNA and RNA damage. It is formed when Reactive Oxygen Species (ROS), such as hydroxyl radicals, attack the C8 position of guanine—the nucleobase most susceptible to oxidation due to its low redox potential. Research into 8-hydroxy-2'-deoxyguanosine (8-OHdG) and 8-hydroxyguanosine (8-OHG) is essential for understanding the molecular mechanisms of genomic instability and cellular aging. Because 8-OHG can pair with adenine instead of cytosine during replication, it often leads to G:C to T:A transversions, making it a highly mutagenic lesion and a driver of carcinogenesis. Beyond cancer research, 8-OHG is a vital tool in studying neurodegenerative diseases, including Alzheimer’s (AD) and Parkinson’s (PD), as well as metabolic syndrome and chronic inflammation. This mouse monoclonal antibody provides high-sensitivity detection of oxidative modifications across various applications, including Immunohistochemistry (IHC), Immunofluorescence (IF), and ELISA, allowing researchers to quantify oxidative nucleic acid damage in tissue and cellular models.