Anti-Amyloid β 1-42 [Clone Ab42.2] - 100 μg

Accumulation and aggregation of amyloid beta (Aβ) in the brain is indicated as the trigger of a pathological cascade that causes Alzheimer disease (AD) . The highly amyloidogenic 42-amino acid form of Aβ (Aβ42) and amino-terminally truncated forms of Aβ (Aβx-42) are the predominant species of Aβ typically found in diffuse and senile plaques within the AD brain. The relative levels of Aβ42 appear to be the key regulators of Aβ aggregation into amyloid; thus Aβ42 has been implicated as the initiating molecule in the pathogenesis of AD.