Anti-AF4 [Clone C2.1.1] - 100 μg

The AF4 and ENL (Eleven nineteen Leukemia) protein families are the most frequent MLL fusion partners accounting for two-thirds of MLL-associated leukemia incidence. AF4 (also known as FEL) is a gene which was first described as a fusion partner with MLL in the t (4;11) acute leukemia. Based on analysis by Northern blotting, AF4 mRNAs were found to be widely expressed in hematopoietic cells and normal human tissues. cDNA sequence analysis of the AF4 gene showed that it encodes a serine/proline-rich protein with a predicted size of 130-140kDa containing guanosine triphosphate (GTP) -binding and putative nuclear-localization sequences. Studies have demonstrated that a related gene, LAF4, isolated from Burkitt's lymphoma, shares high degree of sequence homology with AF4. LAF4 was shown to possess DNA binding ability and transcriptional activation potential. Both AF4 and LAF4 were shown to be evolutionary conserved in vertebrates suggesting an important functional role of the genes.