Recombinant Human PTHrP - 50 μg

Parathyroid Hormone-Related Protein (PTHrP) is a versatile, multifunctional protein hormone expressed and secreted by a wide range of tissues throughout the body, including epithelium, mesenchyme, vascular smooth muscle, and the central nervous system. It plays critical roles in both fetal and postnatal life . Key Biological Functions of PTHrP PTHrP is essential in several physiological systems: Vascular & Smooth Muscle Regulation: PTHrP is often secreted by smooth muscle cells (e.g., in the vasculature) in response to stretching. It acts as a powerful vasodilator by promoting the relaxation of vascular smooth muscle, significantly contributing to the cardiovascular system's function. It is also implicated in the contraction of other smooth muscles, such as those in the bladder, uterus, and heart. Skeletal Development & Bone Health: PTHrP is vital for skeletal development, regulating the proliferation and differentiation within the cranial growth plate. Furthermore, it exhibits potent anabolic effects on bone, showing promise in treating conditions like postmenopausal osteoporosis. It promotes the recruitment of osteogenic cells and prevents the apoptotic death of crucial bone cells (osteoblasts and osteocytes) . Disease Involvement: PTHrP is a key molecular player in several pathological states, most notably Humoral Hypercalcemia of Malignancy (HHM) : PTHrP is a primary causative factor for this paraneoplastic syndrome, leading to elevated calcium levels. Cancer Cachexia: Independent of hypercalcemia, PTHrP contributes to cachexia, a debilitating condition characterized by reduced food intake, body weight loss, and decreased locomotor activity.