AZA1

AZA1 is a potent dual inhibitor of Rac1 and Cdc42. AZA1 induces prostate cancer cells apoptosis and inhibits prostate cancer cells proliferation, migration and invasion[1][2].

Product Specifications

CAS Number

[1071098-42-4]

Product Name Alternative

Rac1/Cdc42-IN-1

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Ras

Type

Reference compound

Related Pathways

Apoptosis; GPCR/G Protein; MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/aza1.html

Concentration

10mM

Purity

98.17

Solubility

DMSO : 50 mg/mL (ultrasonic) |Methanol : 5 mg/mL (ultrasonic; adjust pH to 6 with HCl)

Smiles

CC(N1)=CC2=C1C=CC(NC3=NC(NC4=CC5=C(NC(C)=C5)C=C4)=NC=C3)=C2

Molecular Formula

C22H20N6

Molecular Weight

368.43

Precautions

H302, H315, H319, H335

References & Citations

[1]Zins K, et al. A Rac1/Cdc42 GTPase-specific small molecule inhibitor suppresses growth of primary human prostate cancer xenografts and prolongs survival in mice. PLoS One. 2013;8 (9) :e74924. Published 2013 Sep 11.|[2]Suzuki O, et al. Sialylation and glycosylation modulate cell adhesion and invasion to extracellular matrix in human malignant lymphoma: Dependency on integrin and the Rho GTPase family. Int J Oncol. 2015;47 (6) :2091‐2099.