Tyrosylleucine (TFA)

Tyrosylleucine (Tyr-Leu, YL) TFA, an orally active dipeptide, exhibits a potent antidepressant-like activity[1].

Product Specifications

CAS Number

[66852-01-5]

Product Name Alternative

Tyr-Leu (TFA)

UNSPSC

12352209

Target

Others

Type

Peptides

Related Pathways

Others

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/tyrosylleucine-tfa.html

Purity

98.05

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC(C[C@H](NC([C@@H](N)CC1=CC=C(C=C1)O)=O)C(O)=O)C.O=C(O)C(F)(F)F

Molecular Formula

C17H23F3N2O6

Molecular Weight

408.37

References & Citations

[1]Takafumi Mizushige, et al. Dipeptide tyrosyl-leucine exhibits antidepressant-like activity in mice. Sci Rep. 2020 Feb 10;10 (1) :2257.|[2]Norimasa Kanegawa, et al. Dipeptide Tyr-Leu (YL) exhibits anxiolytic-like activity after oral administration via activating serotonin 5-HT1A, dopamine D1 and GABAA receptors in mice. FEBS Lett. 2010 Feb 5;584 (3) :599-604.