TAME hydrochloride
TAME hydrochloride is an inhibitor of anaphase-promoting complex/cyclosome (APC/C or APC), which binds to APC/C and prevents its activation by Cdc20 and Cdh1, produces mitotic arrest. TAME hydrochloride is not cell permeable[1][2].
Product Specifications
CAS Number
[1784-03-8]
UNSPSC
12352005
Hazard Statement
H317, H319
Target
APC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/TAME_hydrochloride.html
Concentration
10mM
Purity
98.31
Solubility
DMSO : 155 mg/mL (ultrasonic) |H2O : ≥ 100 mg/mL
Smiles
CC1=CC=C(C=C1)S(N[C@H](C(OC)=O)CCCNC(N)=N)(=O)=O.[H]Cl
Molecular Formula
C14H23ClN4O4S
Molecular Weight
378.87
Precautions
H317, H319
References & Citations
[1]Zeng X, et al. Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damage. Cancer Cell. 2010 Oct 19;18 (4) :382-95.|[2]Zeng X, et al. An APC/C inhibitor stabilizes cyclin B1 by prematurely terminating ubiquitination. Nat Chem Biol. 2012 Feb 26;8 (4) :383-92.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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