Anabasine

Anabasine ((S) -Anabasine) is an alkaloid that found as a minor component in tobacco (Nicotiana) . Anabasine is a botanical pesticide nicotine, acts as a full agonist of nicotinic acetylcholine receptors (nAChRs) . Anabasine induces depolarization of TE671 cells endogenously expressing human fetal muscle-type nAChRs (EC50=0.7 μM) [1][2].

Product Specifications

CAS Number

[494-52-0]

Product Name Alternative

(S) -Anabasine; (+) -Anabasine

UNSPSC

12352005

Hazard Statement

H300, H310, H411

Target

NAChR

Type

Natural Products

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Anabasine.html

Purity

99.87

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C1([C@H]2NCCCC2)=CC=CN=C1

Molecular Formula

C10H14N2

Molecular Weight

162.24

Precautions

H300, H310, H411

References & Citations

[1]Levin ED, et al. Effects of tobacco smoke constituents, anabasine and anatabine, on memory and attention in female rats. J Psychopharmacol. 2014 Oct;28 (10) :915-22.|[2]Benedict T Green, et al. Actions of piperidine alkaloid teratogens at fetal nicotinic acetylcholine receptors. Neurotoxicol Teratol. May-Jun 2010;32 (3) :383-90.