11-Deoxy-16,16-dimethyl-PGE2

11-Deoxy-16,16-dimethyl-PGE2, a Prostaglandin E2 analog, is a EP2 and EP3 receptors agonist. 11-Deoxy-16,16-dimethyl-PGE2 protects proximal renal tubular epithelial cells from potent nephrotoxicity-induced cell damage by exerting anti-oxidative stress[1][2].

Product Specifications

CAS Number

[53658-98-3]

UNSPSC

12352211

Hazard Statement

H225-H319-H336-H360

Target

Prostaglandin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/11-deoxy-16-16-dimethyl-pge2.html

Solubility

10 mM in DMSO

Smiles

CCCCC(C)(C)[C@H](O)/C=C/[C@@H]1[C@H](C(CC1)=O)C/C=C\CCCC(O)=O

Molecular Formula

C22H36O4

Molecular Weight

364.52

Precautions

P210-P233-P240-P241-P242-P243-P261-P264-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P370+P378-P403+P233-P403+P235-P405-P501

References & Citations

[1]R F Parrott, et al. Effects of centrally administered prostaglandin EP receptor agonists on febrile and adrenocortical responses in the prepubertal pig. Brain Res Bull. 1996;41 (2) :97-103. |[2]Kelly M Towndrow, et al. 11-Deoxy,16,16-dimethyl prostaglandin E2 induces specific proteins in association with its ability to protect against oxidative stress. Chem Res Toxicol. 2003 Mar;16 (3) :312-9.