Potassium oxonate
Potassium oxonate (Potassium azaorotate) is a uricase inhibitor that inhibits the phosphorylation of 5-FU to 5-fluorouridine-5'-monophosphate.
Product Specifications
CAS Number
2207-75-2
Product Name Alternative
Potassium azaorotate; Potassium otastat; Oteracil potassium
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Xanthine Oxidase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/Oxonic-acid-potassium-salt.html
Purity
99.94
Solubility
DMSO : < 1 mg/mL (ultrasonic; warming; heat to 80°C) |H2O : 3.33 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(O[K])C1=NC(O)=NC(O)=N1
Molecular Formula
C4H2KN3O4
Molecular Weight
195.17
Precautions
H302, H315, H319, H335
References & Citations
[1]Shirasaka T, et al. Inhibition by oxonic acid of gastrointestinal toxicity of 5-fluorouracil without loss of its antitumor activity in rats. Cancer Res. 1993 Sep 1;53 (17) :4004-9.|[2]Eraranta A, et al. Oxonic acid-induced hyperuricemia elevates plasma aldosterone in experimental renal insufficiency. J Hypertens. 2008 Aug;26 (8) :1661-8.|[3]Yoshisue K, et al. Tissue distribution and biotransformation of potassium oxonate after oral administration of a novel antitumor agent (drug combination of tegafur, 5-chloro-2,4-dihydroxypyridine, and potassium oxonate) to rats. Drug Metab Dispos. 2000 Oct;28 (10) :1162-7.|[4]Chen Y, et al. Curcumin attenuates potassium oxonate-induced hyperuricemia and kidney inflammation in mice. Biomed Pharmacother. 2019 Oct;118:109195.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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