Potassium oxonate

Potassium oxonate (Potassium azaorotate) is a uricase inhibitor that inhibits the phosphorylation of 5-FU to 5-fluorouridine-5'-monophosphate.

Product Specifications

CAS Number

[2207-75-2]

Product Name Alternative

Potassium azaorotate; Potassium otastat; Oteracil potassium

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Xanthine Oxidase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/Oxonic-acid-potassium-salt.html

Purity

99.94

Solubility

DMSO : < 1 mg/mL (ultrasonic; warming; heat to 80°C) |H2O : 3.33 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(O[K])C1=NC(O)=NC(O)=N1

Molecular Formula

C4H2KN3O4

Molecular Weight

195.17

Precautions

H302, H315, H319, H335

References & Citations

[1]Shirasaka T, et al. Inhibition by oxonic acid of gastrointestinal toxicity of 5-fluorouracil without loss of its antitumor activity in rats. Cancer Res. 1993 Sep 1;53 (17) :4004-9.|[2]Eraranta A, et al. Oxonic acid-induced hyperuricemia elevates plasma aldosterone in experimental renal insufficiency. J Hypertens. 2008 Aug;26 (8) :1661-8.|[3]Yoshisue K, et al. Tissue distribution and biotransformation of potassium oxonate after oral administration of a novel antitumor agent (drug combination of tegafur, 5-chloro-2,4-dihydroxypyridine, and potassium oxonate) to rats. Drug Metab Dispos. 2000 Oct;28 (10) :1162-7.|[4]Chen Y, et al. Curcumin attenuates potassium oxonate-induced hyperuricemia and kidney inflammation in mice. Biomed Pharmacother. 2019 Oct;118:109195.