5-Aminolevulinic acid (hydrochloride)

5-Aminolevulinic acid hydrochloride (5-ALA hydrochloride) is an intermediate in heme biosynthesis in the body and the universal precursor of tetrapyrroles.

Product Specifications

CAS Number

[5451-09-2]

Product Name Alternative

5-ALA (hydrochloride) ; δ-Aminolevulinic acid (hydrochloride) ; 5-Amino-4-oxopentanoic acid (hydrochloride)

UNSPSC

12352211

Hazard Statement

H315, H319

Target

Apoptosis; Autophagy; Endogenous Metabolite; Mitophagy

Type

Natural Products

Related Pathways

Apoptosis; Autophagy; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Metabolic Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/5-aminolevulinic-acid-hydrochloride.html

Purity

99.61

Solubility

DMSO : 250 mg/mL (ultrasonic) |H2O : 16.67 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(O)CCC(CN)=O.[H]Cl

Molecular Formula

C5H10ClNO3

Molecular Weight

167.59

Precautions

H315, H319

References & Citations

[1]Stummer, W., et al., Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial. Lancet Oncol, 2006. 7 (5) : p. 392-401.|[2]Eyupoglu, I.Y., et al., Improving the extent of malignant glioma resection by dual intraoperative visualization approach. PLoS One, 2012. 7 (9) : p. e44885.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Natural Products

Clinical Information

Launched

Isoform

Human Endogenous Metabolite

Citation 01

Adv Sci (Weinh) . 2019 Jan 20;6 (5) :1802057. |Asian J Androl. 2025 Jul 1;27 (4) :454-463.|Cell Death Dis. 2021 Oct 25;12 (11) :999.|EMBO Mol Med. 2023 Mar 8;15 (3) :e16959.|Genome Biol. 2022 Dec 15;23 (1) :259.|Mar Drugs. 2025 Mar 28;23 (4) :146.|Photodiagnosis Photodyn Ther. 2022 Dec:40:103053.|Photodiagnosis Photodyn Ther. 2023 Jun:42:103612.|Photodiagnosis Photodyn Ther. 2024 Jun:47:104093.|Photodiagnosis Photodyn Ther. 2025 Apr 19:104599.|Photodiagnosis Photodyn Ther. 2025 Aug:54:104726.|bioRxiv. 2024 Apr 3:2023.06.02.542933.|J Inorg Biochem. 2023 Oct:247:112340.|Lasers Med Sci. 2021 Dec;36 (9) :1873-1881.|Nature. 2025 Jul;643 (8070) :192-200.|Pharmacol Res. 2021 Aug:170:105701.|PLoS Biol. 2024 Jun 27;22 (6) :e3002672.