Fipronil
Fipronil is a broad-spectrum insecticide effective against Lepidoptera species as well as thrips, locusts, ants, cockroaches, fleas and ticks. Fipronil selectively inhibits GABA receptor with IC50s of 30 nM and 1600 nM for cockroach and rat GABA receptors, respectively. Glutamate-gated chloride channels (GluCls), which are present in cockroaches but not in mammals, are sensitive to the blocking effect of Fipronil. Fipronil also induces apoptosis in HepG2 cells and promotes the expression of CYP1A1 and CYP3A4 mRNA in human hepatocytes[1][2].
Product Specifications
CAS Number
120068-37-3
UNSPSC
12352005
Hazard Statement
H301+H311+H331, H372
Target
Apoptosis; Cytochrome P450; GABA Receptor
Type
Reference compound
Related Pathways
Apoptosis; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/fipronil.html
Purity
99.49
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
N#CC1=NN(C2=C(Cl)C=C(C(F)(F)F)C=C2Cl)C(N)=C1S(C(F)(F)F)=O
Molecular Formula
C12H4Cl2F6N4OS
Molecular Weight
437.15
Precautions
H301+H311+H331, H372
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
CYP1; CYP2; CYP3
Available Sizes
Frequently Asked Questions
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