IRAK1-IN-1

IRAK1-IN-1 (compound B8) is an orally active IRAK1 inhibitor. IRAK1-IN-1 inhibits the release of IL-6 with the IC50 values of 4.57 μM and 6.51 μM on mouse cells J774A. 1 and human cells THP-1, respectively. IRAK1-IN-1 alleviats LPS (HY-D1056) -induced acute lung injury (ALI) and DSS (HY-116282C) -induced colitis in mice[1].

Product Specifications

UNSPSC

12352005

Target

IRAK

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/irak1-in-1.html

Smiles

CC(N1CCN(CC1)CCOC2=CC(OC3=CC=CC=C23)=O)=O

Molecular Formula

C17H20N2O4

Molecular Weight

316.35

References & Citations

[1]Li X, et al. Design, synthesis and bioactivity evaluation of 4-hydroxycoumarin derivatives as potential anti-inflammatory agents against acute lung injury and colitis. Eur J Med Chem. 2024;272:116487.