RAF265

RAF265 is a potent and orally active RAF/VEGFR2 inhibitor.

Product Specifications

CAS Number

[927880-90-8]

Product Name Alternative

CHIR-265

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Autophagy; Raf; VEGFR

Type

Reference compound

Related Pathways

Apoptosis; Autophagy; MAPK/ERK Pathway; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/RAF265.html

Purity

99.80

Solubility

DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C) |Ethanol : 10 mg/mL (ultrasonic)

Smiles

FC(F)(C1=CN=C(N1)C2=NC=CC(OC3=CC=C4N(C(NC5=CC=C(C(F)(F)F)C=C5)=NC4=C3)C)=C2)F

Molecular Formula

C24H16F6N6O

Molecular Weight

518.41

Precautions

H302, H315, H319, H335

References & Citations

[1]Mordant P, et al. Dependence on phosphoinositide 3-kinase and RAS-RAF pathways drive the activity of RAF265, a novel RAF/VEGFR2 inhibitor, and RAD001 (Everolimus) in combination. Mol Cancer Ther. 2010 Feb;9 (2) :358-68.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Phase 2

Isoform

Raf; VEGFR2/KDR/Flk-1

Available Sizes

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