RAF265
Product Specifications
UNSPSC Description
RAF265 is a potent and orally active RAF/VEGFR2 inhibitor.
Target Antigen
Apoptosis; Autophagy; Raf; VEGFR
Type
Reference compound
Related Pathways
Apoptosis;Autophagy;MAPK/ERK Pathway;Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/RAF265.html
Purity
99.80
Solubility
DMSO : ≥ 26 mg/mL|Ethanol : 10 mg/mL (ultrasonic)
Smiles
FC(F)(C1=CN=C(N1)C2=NC=CC(OC3=CC=C4N(C(NC5=CC=C(C(F)(F)F)C=C5)=NC4=C3)C)=C2)F
Molecular Weight
518.41
References & Citations
[1]Mordant P, et al. Dependence on phosphoinositide 3-kinase and RAS-RAF pathways drive the activity of RAF265, a novel RAF/VEGFR2 inhibitor, and RAD001 (Everolimus) in combination. Mol Cancer Ther. 2010 Feb;9(2):358-68.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-10248/RAF265-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-10248/RAF265-SDS-MedChemExpress.pdf
Clinical Information
Phase 2
CAS Number
927880-90-8
Available Sizes
Curated Selection
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