Xylometazoline (hydrochloride)
Xylometazoline hydrochloride is an α-adrenergic receptor agonist (Ki=0.05-1.7 μM) . Xylometazoline hydrochloride can constrict nasal blood vessels and increase nasal airflow. Xylometazoline hydrochloride can be used in nose stuffiness and runny nose research[1][2][3][4].
Product Specifications
CAS Number
1218-35-5
UNSPSC
12352005
Hazard Statement
H301
Target
Adrenergic Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/xylometazoline-hydrochloride.html
Purity
99.94
Solubility
DMSO : 25 mg/mL (ultrasonic) |H2O : 50 mg/mL (ultrasonic)
Smiles
CC1=C(CC2=NCCN2)C(C)=CC(C(C)(C)C)=C1.Cl
Molecular Formula
C16H25ClN2
Molecular Weight
280.84
Precautions
H301
References & Citations
[1]Ronald Eccles, et al. The nasal decongestant effect of xylometazoline in the common cold. Am J Rhinol. 2008 Sep-Oct;22 (5) :491-6.|[2]Britta Haenisch, et al. Alpha-adrenoceptor agonistic activity of oxymetazoline and xylometazoline. Fundam Clin Pharmacol. 2010 Dec;24 (6) :729-39.|[3]M Kar, et al. Development of an intranasal formulation containing indomethacin and xylometazoline for rhinosinusitis treatment. Eur Rev Med Pharmacol Sci. 2022 Dec;26 (2 Suppl) :65-71.|[4]Ayse Ipek Akyuz Unsal, et al. Ophthalmic adverse effects of nasal decongestants on an experimental rat model. Arq Bras Oftalmol. 2018 Jan-Feb;81 (1) :53-58.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
α adrenergic receptor
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