Nenocorilant
Product Specifications
UNSPSC Description
Nenocorilantis a potent, orally activity glucocorticoid receptor (GR) antagonist with Ki value of 0.15 nM. Nenocorilant has pro-apoptotic effects and improves potency combined with cytotoxic agent. Nenocorilant can be used for cancer research[1][2][3].
Target Antigen
Apoptosis; Caspase; Glucocorticoid Receptor
Type
Reference compound
Related Pathways
Apoptosis;Immunology/Inflammation;Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nenocorilant.html
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=CC(C(F)(F)F)=CC=N1)[C@@]23C(CCN(C3)S(=O)(C4=NN(N=C4)C)=O)=CC5=C(C=NN5C6=CC=C(C=C6)F)C2
Molecular Weight
587.55
References & Citations
[1]Greenstein AE, et, al. Glucocorticoid receptor antagonism promotes apoptosis in solid tumor cells. Oncotarget. 2021 Jun 22;12(13):1243-1255.|[2]Stringer-Reasor EM, et, al. Glucocorticoid receptor activation inhibits chemotherapy-induced cell death in high-grade serous ovarian carcinoma. Gynecol Oncol. 2015 Sep;138(3):656-62.|[3]WHO Drug Information. International Nonproprietary Names for Pharmaceutical
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-147293/Nenocorilant-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-147293/Nenocorilant-SDS-MedChemExpress.pdf
Clinical Information
Phase 2
CAS Number
1496509-78-4
Available Sizes
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