Nenocorilant

Product Specifications

CAS Number

[1496509-78-4]

UNSPSC Description

Nenocorilantis a potent, orally activity glucocorticoid receptor (GR) antagonist with Ki value of 0.15 nM. Nenocorilant has pro-apoptotic effects and improves potency combined with cytotoxic agent. Nenocorilant can be used for cancer research[1][2][3].

Target Antigen

Apoptosis; Caspase; Glucocorticoid Receptor

Type

Reference compound

Related Pathways

Apoptosis;Immunology/Inflammation;Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/nenocorilant.html

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1=CC(C(F)(F)F)=CC=N1)[C@@]23C(CCN(C3)S(=O)(C4=NN(N=C4)C)=O)=CC5=C(C=NN5C6=CC=C(C=C6)F)C2

Molecular Weight

587.55

References & Citations

[1]Greenstein AE, et, al. Glucocorticoid receptor antagonism promotes apoptosis in solid tumor cells. Oncotarget. 2021 Jun 22;12(13):1243-1255.|[2]Stringer-Reasor EM, et, al. Glucocorticoid receptor activation inhibits chemotherapy-induced cell death in high-grade serous ovarian carcinoma. Gynecol Oncol. 2015 Sep;138(3):656-62.|[3]WHO Drug Information. International Nonproprietary Names for Pharmaceutical