Kv2.1-IN-1

Kv2.1-IN-1 is an orally active and blood-brain barrier penetrant Kv2.1 inhibitor with an IC50 of 0.07 μM. Kv2.1-IN-1 exhibits a selectivity >130 fold over other K+, Na+, and Ca2+ ion channels. Kv2.1-IN-1 decreases the apoptosis of HEK293 cells induced by H2O2. Kv2.1-IN-1 produces significant neuroprotection efficacy in middle cerebral artery occlusion (MCAO) rat. Kv2.1-IN-1 can be used for the study of ischemic stroke[1].

Product Specifications

CAS Number

[2252448-93-2]

UNSPSC

12352005

Target

Apoptosis; Potassium Channel

Type

Reference compound

Related Pathways

Apoptosis; Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/kv2-1-in-1.html

Purity

98.64

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1=CC(NC(C(C)C)=O)=CC=C1OCC)NC(C2=CC=CC(NC)=C2)C

Molecular Formula

C22H29N3O3

Molecular Weight

383.48

References & Citations

[1]Jie Zhou, et al. Discovery of 2-Ethoxy-5-isobutyramido-N-1-substituted Benzamide Derivatives as Selective Kv2.1 Inhibitors with In Vivo Neuroprotective Effects. J Med Chem. 2023 Dec 27.