Big Endothelin-2 (Human, 1-37)

<strong>Big Endothelin-2 (Human, 1-37)</strong> <strong>Catalog number:</strong> MDP0610 <strong>CAS Number: </strong>159899-65-7 <strong>Sequence: </strong>Cys-Ser-Cys-Ser-Ser-Trp-Leu-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp-Val-Asn-Thr-Pro-Glu-Gln-Thr-Ala-Pro-Tyr-Gly-Leu-Gly-Asn-Pro-Pro (Disulfide bonds between Cys1-Cys15 and Cys3-Cys11) <strong>Amount:</strong> 100 ug <strong>Molecular Weight:</strong> 4183.6 g/mol <strong>Supplied as:</strong> Powder <strong>Applications:</strong> molecular tool for various biochemical applications <strong>Storage:</strong> -20 °C <strong>WARNING:</strong> For in vitro Research Use Only. NOT for use on humans or animals. <strong>Grade:</strong> Biotechnology grade. All products are highly pure. <strong>References:</strong> 1: Miyauchi Y, Sakai S, Maeda S, Shimojo N, Watanabe S, Honma S, Kuga K, Aonuma K, Miyauchi T. Increased plasma levels of big-endothelin-2 and big-endothelin-3 in patients with end-stage renal disease Life Sci. 2012 Oct 15;91(13-14):729-32. 2: Takai S, Shiota N, Jin D, Miyazaki M. Chymase processes big-endothelin-2 to endothelin-2-(1-31) that induces contractile responses in the isolated monkey trachea Eur J Pharmacol. 1998 Oct 9;358(3):229-33. 3: Yap EY, Battistini B, McKay KO. Contraction to big endothelin-1, big endothelin-2 and big endothelin-3, and endothelin-converting enzyme inhibition in human isolated bronchi Br J Pharmacol. 2000 Jan;129(1):170-6. 4: Gratton JP, Rae GA, Bkaily G, D'Orléans-Juste P. ET(B) receptor blockade potentiates the pressor response to big endothelin-1 but not big endothelin-2 in the anesthetized rabbit Hypertension. 2000 Mar;35(3):726-31. 5: Gratton JP, Rae GA, Claing A, Télémaque S, D'Orléans-Juste P. Different pressor and bronchoconstrictor properties of human big-endothelin-1, 2 (1-38) and 3 in ketamine/xylazine-anaesthetized guinea-pigs Br J Pharmacol. 1995 Feb;114(3):720-6. 6: Yorimitsu K, Shinmi O, Nishiyama M, Moroi K, Sugita Y, Saito T, Inagaki Y, Masaki T, Kimura S. Effect of phosphoramidon on big endothelin-2 conversion into endothelin-2 in human renal adenocarcinoma (ACHN) cells. Analysis of endothelin-2 biosynthetic pathway FEBS Lett. 1992 Dec 21;314(3):395-8. 7: Plumpton C, Ashby MJ, Kuc RE, O'Reilly G, Davenport AP. Expression of endothelin peptides and mRNA in the human heart Clin Sci (Lond). 1996 Jan;90(1):37-46. 8: Aubin P, Le Brun G, Moldovan F, Villette JM, Créminon C, Dumas J, Homyrda L, Soliman H, Azizi M, Fiet J. Sandwich-type enzyme immunoassay for big endothelin-I in plasma: concentrations in healthy human subjects unaffected by sex or posture Clin Chem. 1997 Jan;43(1):64-70. 9: Mattera GG, Eglezos A, Renzetti AR, Mizrahi J. Comparison of the cardiovascular and neural activity of endothelin-1, -2, -3 and respective proendothelins: effects of phosphoramidon and thiorphan Br J Pharmacol. 1993 Sep;110(1):331-7. <a href="https://pubmed.ncbi.nlm.nih.gov/8407980">10: Takahashi M, Matsushita Y, Iijima Y, Tanzawa K. Purification and characterization of endothelin-converting enzyme from rat lung J Biol Chem. 1993 Oct 5;268(28):21394-8.</a> <br><strong>Products Related to Big Endothelin-2 (Human, 1-37) can be found at</strong> <a href="https://moleculardepot.com/product-category/Peptides/"> Peptides</a>