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MCH (human, mouse, rat)

MCH (human, mouse, rat) is a potent peptide agonist of MCH-R and exhibits binding IC50 values of 0.3nM and 1.5 nM for MCH1R and MCH2R, respectively. MCH (human, mouse, rat) is a highly sensitive to MCH-2R in a CHO cell line and monitoring mobilization of intracellular calcium with FLIPR, exhibits functional activation EC50 values of 3.9 nM and 0.1nM for human MCH-1R and MCH-2R, respectively[1].

Product Specifications

CAS Number

[128315-56-0]

Product Name Alternative

Melanin-concentrating hormone (human, mouse, rat)

UNSPSC

12352209

Target

MCHR1 (GPR24)

Type

Peptides

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/mch-human-mouse-rat.html

Solubility

10 mM in DMSO

Smiles

O=C([C@H]1NC(C2([H])N(CCC2)C([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@H](CSSC1)NC([C@H](CCCNC(N)=N)NC([C@H](CC(C)C)NC([C@H](CCSC)NC([C@H](CC(O)=O)NC([C@@H](NC([C@@H](N)CC(O)=O)=O)CC3=CC=CC=C3)=O)=O)=O)=O)=O)=O)CCSC)=O)CC(C)C)=O)=O)CCCNC(N)=N)=O)C(C)C)=O)CC4=CC=C(C=C4)O)=O)CCCNC(N)=N)=O)=O)N[C@H](C(N[C@@H](CCC(N)=O)C(N[C@H](C(O)=O)C(C)C)=O)=O)CC5=CNC6=CC=CC=C56

Molecular Formula

C105H160N30O26S4

Molecular Weight

2386.84

References & Citations

[1]A W Sailer, et al. Identification and characterization of a second melanin-concentrating hormone receptor, MCH-2R. Proc Natl Acad Sci U S A. 2001 Jun 19;98 (13) :7564-9.

Shipping Conditions

Room temperature

Scientific Category

Peptides

Clinical Information

No Development Reported

Curated Selection

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