DB818 (dihydrochloride)

DB818 dihydrochloride is the dihydrochloride salt form of DB818 (HY-122623) . DB818 dihydrochloride is an inhibitor for Homeobox A9 (HOXA9) . DB818 dihydrochloride reduces the formation of HOXA9-DNA complexes, inhibits the growth and induces apoptosis in AML cell lines OCI/AML3, MV4-11, and THP-1[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/db818-dihydrochloride.html

Purity

99.99

Solubility

H2O : 5 mg/mL (ultrasonic;warming)

Smiles

N=C(C1=CC=C(C2=CC=C(C3=NC4=CC=C(C(N)=N)C=C4N3)S2)C=C1)N.Cl.Cl

Molecular Formula

C19H18Cl2N6S

Molecular Weight

433.36

References & Citations

[1]Sonoda Y, et al. Effects of HOXA9 Inhibitor DB818 on the Growth of Acute Myeloid Leukaemia Cells. Anticancer Res. 2021 Apr;41 (4) :1841-1847.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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