DB818 (dihydrochloride)
DB818 dihydrochloride is the dihydrochloride salt form of DB818 (HY-122623) . DB818 dihydrochloride is an inhibitor for Homeobox A9 (HOXA9) . DB818 dihydrochloride reduces the formation of HOXA9-DNA complexes, inhibits the growth and induces apoptosis in AML cell lines OCI/AML3, MV4-11, and THP-1[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/db818-dihydrochloride.html
Purity
99.99
Solubility
H2O : 5 mg/mL (ultrasonic;warming)
Smiles
N=C(C1=CC=C(C2=CC=C(C3=NC4=CC=C(C(N)=N)C=C4N3)S2)C=C1)N.Cl.Cl
Molecular Formula
C19H18Cl2N6S
Molecular Weight
433.36
References & Citations
[1]Sonoda Y, et al. Effects of HOXA9 Inhibitor DB818 on the Growth of Acute Myeloid Leukaemia Cells. Anticancer Res. 2021 Apr;41 (4) :1841-1847.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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