DB818 (dihydrochloride)
Product Specifications
UNSPSC Description
DB818 dihydrochloride is the dihydrochloride salt form of DB818 (HY-122623). DB818 dihydrochloride is an inhibitor for Homeobox A9 (HOXA9). DB818 dihydrochloride reduces the formation of HOXA9-DNA complexes, inhibits the growth and induces apoptosis in AML cell lines OCI/AML3, MV4-11, and THP-1[1].
Target Antigen
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/db818-dihydrochloride.html
Purity
99.43
Solubility
H2O : 5 mg/mL (ultrasonic;warming)
Smiles
N=C(C1=CC=C(C2=CC=C(C3=NC4=CC=C(C(N)=N)C=C4N3)S2)C=C1)N.Cl.Cl
Molecular Weight
433.36
References & Citations
[1]Sonoda Y, et al. Effects of HOXA9 Inhibitor DB818 on the Growth of Acute Myeloid Leukaemia Cells. Anticancer Res. 2021 Apr;41(4):1841-1847.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-122623A/DB818-dihydrochloride-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-122623A/
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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