EGFR, Human (T790M, L858R, sf9, Strep II, GST, His)

The EGFR protein is a receptor tyrosine kinase that can bind to a variety of ligands, such as EGF, TGFA, AREG, epigen, BTC, epiregulin, and HBEGF, to initiate signaling cascades that mediate cellular responses. This involves receptor dimerization, autophosphorylation and recruitment of adapter proteins such as GRB2, activating downstream pathways such as RAS-RAF-MEK-ERK, PI3-kinase-AKT, PLCgamma-PKC and STAT. EGFR Protein, Human (T790M, L858R, sf9, Strep II, GST, His) is the recombinant human-derived EGFR, expressed by Sf9 insect cells, with C-8*His, N-GST, N-Strep II labeled tag.