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Bucladesine (sodium)

Bucladesine sodium salt (Dibutyryl-cAMP sodium salt) is a stabilized cyclic AMP (cAMP) analog and a selective PKA activator. Bucladesine sodium salt raises the intracellular levels of cAMP. Bucladesine sodium salt is also a phosphodiesterase (PDE) inhibitor. Bucladesine sodium salt has anti-inflammatory activity and can be used for impaired wound healing[1][2][3][4].

Product Specifications

CAS Number

16980-89-5

Product Name Alternative

Dibutyryl cAMP (sodium salt) ; DBcAMP (sodium salt)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Phosphodiesterase (PDE) ; PKA

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; Stem Cell/Wnt; TGF-beta/Smad

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Bucladesine-sodium-salt.html

Purity

99.36

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : ≥ 100 mg/mL

Smiles

O=C(CCC)O[C@H]1[C@H](N2C(N=CN=C3NC(CCC)=O)=C3N=C2)O[C@@](CO4)([H])[C@@]1([H])OP4(O[Na])=O

Molecular Formula

C18H23N5NaO8P

Molecular Weight

491.37

Precautions

H302, H315, H319, H335

References & Citations

[1]Sharifzadeh, M., et al., Post-training intrahippocampal infusion of nicotine-bucladesine combination causes a synergistic enhancement effect on spatial memory retention in rats. Eur J Pharmacol, 2007. 562 (3) : p. 212-20.|[2]Mafune, E., M. Takahashi, and N. Takasugi, Effect of vehicles on percutaneous absorption of bucladesine (dibutyryl cyclic AMP) in normal and damaged rat skin. Biol Pharm Bull, 1995. 18 (11) : p. 1539-43.|[3]Rundfeldt, C., et al., The stable cyclic adenosine monophosphate analogue, dibutyryl cyclo-adenosine monophosphate (bucladesine), is active in a model of acute skin inflammation. Arch Dermatol Res, 2012.|[4]Salehi F, et al. Effect of bucladesine, pentoxifylline, and H-89 as cyclic adenosine monophosphate analog, phosphodiesterase, and protein kinase A inhibitor on acute pain. Fundam Clin Pharmacol. 2017 Aug;31 (4) :411-419.|[5]Shimojo M, et al. The cholinergic gene locus is coordinately regulated by protein kinase A II in PC12 cells. J Neurochem. 1998 Sep;71 (3) :1118-26.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

Launched

Isoform

PKA

Citation 01

Adv Sci (Weinh) . 2021 Dec;8 (24) :e2100808.|Adv Sci (Weinh) . 2025 Apr 28:e2409837.|Biochem Biophys Res Commun. 2025 Sep 19:785:152676.|bioRxiv. 2024 Mar 31.|Cell Commun Signal. 2022 Apr 12;20 (1) :52.|Cell Stem Cell. 2021 Aug 5;28 (8) :1362-1379.e7.|Cell Tissue Res. 2022 May;388 (2) :453-469.|Cells. 2024 Jul 26;13 (15) :1260.|Chem Biol Interact. 2025 Sep 20:111749.|Dev Cell. 2025 Sep 3:S1534-5807 (25) 00530-1.|Ecotoxicol Environ Saf. 2022 Sep 15:243:113982.|Eur J Pharmacol. 2022 Oct 15:932:175231.|FASEB J. 2020 Oct;34 (10) :13376-13395.|FASEB J. 2024 May 15;38 (9) :e23622.|FEBS Lett. 2021 Nov;595 (22) :2829-2843.|Front Microbiol. 2021 Aug 17;12:692693.|Genomics. 2025 Jan 21;117 (2) :111002.|Int J Biol Sci. 2024 Aug 19;20 (11) :4476-4495.|Int J Mol Sci. 2022 Oct 20;23 (20) :12595.|Int J Mol Sci. 2023 Feb 8;24 (4) :3398.|Int J Mol Sci. 2023 Mar 7;24 (6) :5111.|J Assist Reprod Genet. 2024 Jun;41 (6) :1669-1685.|J Bone Miner Metab. 2021 Sep;39 (5) :748-756.|J Endocrinol. 2019 Sep 1; JOE-19-0284.R2.|J Steroid Biochem Mol Biol. 2023 Jan:225:106192.|Life Sci. 2025 Oct 14:382:124022.|Mol Cell Endocrinol. 2025 May 19:112581.|Pigment Cell Melanoma Res. 2024 Jan;37 (1) :21-35.|Plants. 2023 Oct 24;12 (21) :3666.|Proteome Sci. 2023 Oct 11;21 (1) :16.|protocols.io. 2024 Jan 12.|Reproduction. 2021 May 27;162 (1) :33-45.|Res Sq. 2024 Jun 11.|SSRN. 2025 Jan 27.|Toxicology. 2025 Jan 29:154069.|Toxins. 2021 Aug 22;13 (8) :585.|Exp Ther Med. 2022 Apr;23 (4) :248.|Front Endocrinol. 2025 Feb 19:16:1570284.

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