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Fusidic acid (sodium salt)

Selected Variant

HY-B1350A-01

Size: 100 mg

Fusidic acid sodium salt is an orally available antibacterial agent that inhibits bacterial protein synthesis by preventing the release of translation elongation factor G (EF-G) from ribosomes. Fusidic acid sodium salt inhibits the inhibitory and activating effects of interleukins IL-1 and IL-6 on glucose-induced insulin production and exhibits antidiabetic effects in a rat model. Fusidic acid sodium salt improves the symptoms of colitis in rats and inhibits the growth of Toxoplasma gondii and Listeria monocytogenes EGD in vitro, but not in mice[1][2][3][4][5][6].

Product Specifications

CAS Number

751-94-0

Product Name Alternative

Sodium fusidate; SQ-16360

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Antibiotic; Bacterial; Interleukin Related

Type

Natural Products

Related Pathways

Anti-infection; Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Fusidic-acid-sodium-salt.html

Concentration

10mM

Purity

99.64

Solubility

DMSO : ≥ 100 mg/mL|H2O : ≥ 100 mg/mL

Smiles

C[C@@H]([C@]1([H])CC[C@]([C@@](C[C@@H]/2OC(C)=O)3C)4C)[C@H](O)CC[C@]1(C)[C@]4([H])[C@H](O)C[C@@]3([H])C2=C(C(O[Na])=O)/CC/C=C(C)\C

Molecular Formula

C31H47NaO6

Molecular Weight

538.69

Precautions

H302, H315, H319, H335

References & Citations

[1] J Turnidge, et al. Fusidic acid pharmacology, pharmacokinetics and pharmacodynamics. Int J Antimicrob Agents. 1999 Aug:12 Suppl 2:S23-34.|[2]P Collignon, et al. Fusidic acid in vitro activity. Int J Antimicrob Agents. 1999 Aug:12 Suppl 2:S45-58.|[3]K Bendtzen, et al. Effect of fusidic acid on interleukin-1 (IL-1) - and IL-6-induced pancreatic beta-cell functions in rats. J Endocrinol. 1992 Mar;132 (3) :345-52.|[4]Amanda J Payne, et al. Fusidic acid is an effective treatment against Toxoplasma gondii and Listeria monocytogenes in vitro, but not in mice. Parasitol Res. 2013 Nov;112 (11) :3859-63.|[5]K Buschard, et al. Anti-diabetogenic effect of fusidic acid in diabetes prone BB rats. Autoimmunity. 1992;14 (2) :101-4.|[6]Roberto Di Marco, et al. Curative effects of sodium fusidate on the development of dinitrobenzenesulfonic acid-induced colitis in rats. Clin Immunol. 2003 Dec;109 (3) :266-71.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Natural Products

Clinical Information

Launched

Isoform

IL-1; IL-6

Citation 01

Adv Sci (Weinh) . 2023 Sep;10 (25) :e2301753.|Cell Rep Med. 2023 Jun 20;4 (6) :101061.|Cell Rep Med. 2023 Jun 20;4 (6) :101061.

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