ELA-21 (human)

ELA-21 (human) is an apelin receptor agonist with a pKi of 8.52. ELA-21 (human) completely inhibits Forskolin-induced cAMP production and stimulates β-arrestin recruitment with subnanomolar potencies. ELA-21 (human) is an agonist in G-protein-dependent and -independent pathways[1].

Product Specifications

CAS Number

[2245073-05-4]

UNSPSC

12352209

Target

Apelin Receptor (APJ) ; Arrestin

Type

Peptides

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/ela-21-human.html

Purity

99.97

Solubility

H2O : 50 mg/mL (ultrasonic)

Smiles

O=C(N1[C@@H](CCC1)C(O)=O)[C@H](CC2=CC=CC=C2)NC([C@H]3N(CCC3)C([C@H](C(C)C)NC([C@H](CCCNC(N)=N)NC([C@H](CO)NC([C@@H](NC([C@H](CC(C)C)NC([C@H]4N(CCC4)C([C@H](CCSC)NC([C@H]5NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CSSC5)NC([C@H](CC(N)=O)NC([C@@H](NC([C@H](CCCCN)NC([C@H](CCCNC(N)=N)NC([C@@H](N)CC(C)C)=O)=O)=O)CC6=CN=CN6)=O)=O)=O)CC(C)C)=O)CCC(N)=O)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)=O)=O)=O)=O)CC7=CN=CN7)=O)=O)=O)=O)=O

Molecular Formula

C112H184N40O25S3

Molecular Weight

2587.11

References & Citations

[1]Peiran Yang, et al. Elabela/Toddler Is an Endogenous Agonist of the Apelin APJ Receptor in the Adult Cardiovascular System, and Exogenous Administration of the Peptide Compensates for the Downregulation of Its Expression in Pulmonary Arterial Hypertension. Circulation. 2017 Mar 21;135 (12) :1160-1173.