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13-Hydroxyisobakuchiol

Hydroxyisobakuchiol (Delta3,2-Hydroxylbakuchiol), an analog of Bakuchiol (HY-N0235) isolated from Psoralea corylifolia (L.), is a potent monoamine transporter inhibitor. 13-Hydroxyisobakuchiol is more selective for the dopamine transporter (DAT) (IC50=0.58 μM) and norepinephrine transporter (NET) (IC50=0.69 μM) than for the serotonin transporter (SERT) (IC50=312.02 μM) . 13-Hydroxyisobakuchiol has the potential for the research of disorders such as Parkinson's disease and depression[1].

Product Specifications

CAS Number

[178765-49-6]

Product Name Alternative

Delta3,2-Hydroxylbakuchiol

UNSPSC

12352005

Target

Dopamine Transporter; Monoamine Transporter

Type

Natural Products

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/13-hydroxyisobakuchiol.html

Solubility

10 mM in DMSO

Smiles

OC1=CC=C(/C=C/[C@](C)(C=C)C/C=C/C(C)(O)C)C=C1

Molecular Formula

C18H24O2

Molecular Weight

272.38

References & Citations

[1]Gang Zhao, et al. Bakuchiol analogs inhibit monoamine transporters and regulate monoaminergic functions. Biochem Pharmacol. 2008 May 1;75 (9) :1835-47.

Shipping Conditions

Room temperature

Scientific Category

Natural Products

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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