Recombinant XRCC1 Protein

<strong>Recombinant XRCC1 Protein</strong>_x000D_ <strong>Catalog number:</strong> B2017741_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 10 µg_x000D_ <strong>Molecular Weight or Concentration:</strong> 72.01 kDa_x000D_ <strong>Supplied as:</strong> Solution_x000D_ <strong>Applications:</strong> a molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> RT_x000D_ <strong>Keywords:</strong> RCC, SCAR26_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Iyama T, Wilson DM 3rd. DNA repair mechanisms in dividing and non-dividing cells DNA Repair (Amst). 2013 Aug;12(8):620-36._x000D_ 2: Cong K, Peng M, Kousholt AN, Lee WTC, Lee S, Nayak S, Krais J, VanderVere-Carozza PS, Pawelczak KS, Calvo J, Panzarino NJ, Turchi JJ, Johnson N, Jonkers J, Rothenberg E, Cantor SB. Replication gaps are a key determinant of PARP inhibitor synthetic lethality with BRCA deficiency Mol Cell. 2021 Aug 5;81(15):3128-3144.e7._x000D_ 3: Caldecott KW, Thompson LH. Partial correction of the single-strand break repair defect in the CHO mutant EM9 by electroporated recombinant XRCC1 protein Ann N Y Acad Sci. 1994 Jul 29;726:336-9._x000D_ 4: Tomkinson AE, Levin DS. Mammalian DNA ligases Bioessays. 1997 Oct;19(10):893-901._x000D_ 5: Abbotts R, Wilson DM 3rd. Coordination of DNA single strand break repair Free Radic Biol Med. 2017 Jun;107:228-244._x000D_ 6: Zhang X, Moréra S, Bates PA, Whitehead PC, Coffer AI, Hainbucher K, Nash RA, Sternberg MJ, Lindahl T, Freemont PS. Structure of an XRCC1 BRCT domain: a new protein-protein interaction module EMBO J. 1998 Nov 2;17(21):6404-11._x000D_ 7: Berquist BR, Singh DK, Fan J, Kim D, Gillenwater E, Kulkarni A, Bohr VA, Ackerman EJ, Tomkinson AE, Wilson DM 3rd. Functional capacity of XRCC1 protein variants identified in DNA repair-deficient Chinese hamster ovary cell lines and the human population Nucleic Acids Res. 2010 Aug;38(15):5023-35._x000D_ 8: Hammel M, Rashid I, Sverzhinsky A, Pourfarjam Y, Tsai MS, Ellenberger T, Pascal JM, Kim IK, Tainer JA, Tomkinson AE. An atypical BRCT-BRCT interaction with the XRCC1 scaffold protein compacts human DNA Ligase IIIα within a flexible DNA repair complex Nucleic Acids Res. 2021 Jan 11;49(1):306-321._x000D_ 9: Wilson DM 3rd, Thompson LH. Molecular mechanisms of sister-chromatid exchange Mutat Res. 2007 Mar 1;616(1-2):11-23._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/24856239">10: Pommier Y, Huang SY, Gao R, Das BB, Murai J, Marchand C. Tyrosyl-DNA-phosphodiesterases (TDP1 and TDP2) DNA Repair (Amst). 2014 Jul;19:114-29. </a>_x000D_ _x000D_ <strong>Products Related to Recombinant XRCC1 Protein can be found at</strong> <a href="https://moleculardepot.com/product-category/Proteins/"> Proteins</a>