LGK974
LGK974 (WNT974) is an orally bioavailable and specific Porcupine (PORCN) inhibitor with an IC50 of 0.1 nM[1].
Product Specifications
CAS Number
[1243244-14-5]
Product Name Alternative
WNT974
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Porcupine
Type
Reference compound
Related Pathways
Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/LGK974.html
Purity
99.93
Solubility
DMSO : 125 mg/mL (ultrasonic) |Ethanol : 8.33 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(NC1=NC=C(C2=NC=CN=C2)C=C1)CC3=CN=C(C4=CC(C)=NC=C4)C(C)=C3
Molecular Formula
C23H20N6O
Molecular Weight
396.45
Precautions
H302, H315, H319, H335
References & Citations
[1]Liu J, et al. Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974. Proc Natl Acad Sci U S A. 2013 Dec 10;110 (50) :20224-9.|[2]Tammela T, et al. A Wnt-producing niche drives proliferative potential and progression in lung adenocarcinoma. Nature. 2017 May 18;545 (7654) :355-359.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Available Sizes
Curated Selection
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