Ruboxyl

Ruboxyl is an anthracycline antibiotic with antitumor activity. Ruboxyl inhibits colorectal cancer (CRC) liver metastasis in mice by 84%, suppresses B16 melanoma growth, and increases the survival rate of mice with L1210 or L5178Y leukemia[1][2].

Product Specifications

CAS Number

[80214-88-6]

UNSPSC

12352005

Target

Antibiotic

Type

Reference compound

Related Pathways

Anti-infection

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ruboxyl.html

Smiles

O=C1C2=C(C3=C(C(O)=C2C(C4=C1C=CC=C4OC)=O)[C@@H](O[C@H]5C[C@@H]([C@@H]([C@@H](O5)C)O)N)C[C@@](/C(C)=N\N=C6CC(C)(N(C(C)(C/6)C)O)C)(O)C3)O.Cl

Molecular Formula

C36H47ClN4O10

Molecular Weight

731.23

References & Citations

[1]Leonetti C, et al. Ruboxyl, a new nitroxyl derivative of daunorubicin - acute toxicity and antitumor effect in animals. Int J Oncol. 1993 Oct;3 (4) :615-8.|[2]Sirovich I, et al. Activity of ruboxyl, a nitroxyl derivative of daunorubicin, on experimental models of colorectal cancer metastases. Tumour Biol. 1999 Sep-Oct;20 (5) :270-6.