N- (5-Hydroxypentyl) maleimide
N- (5-Hydroxypentyl) maleimide is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs), such as Gemcitabine-O-Si (di-iso) -O-Mc (HY-130812) ) [1].
Product Specifications
CAS Number
[180608-78-0]
UNSPSC
12352203
Hazard Statement
H302, H315, H319, H335
Target
ADC Linker
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/n-5-hydroxypentyl-maleimide.html
Purity
99.49
Solubility
10 mM in DMSO
Smiles
OCCCCCN1C(C=CC1=O)=O
Molecular Formula
C9H13NO3
Molecular Weight
183.20
Precautions
H302, H315, H319, H335
References & Citations
[1] Finniss, M. C., et al. A versatile acid-labile linker for antibody–drug conjugates. Med. Chem. Commun., 2014, 5 (9), 1355-1358.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Non-cleavable Linker
Available Sizes
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