(R) -Ofloxacin

(R) -Ofloxacin is the dextrorotatory enantiomer of Ofloxacin (HY-B0125) and is an orally effective fluoroquinolone antibiotic. (R) -Ofloxacin can inhibit the activity of bacterial DNA topoisomerase II, interfere with bacterial DNA replication and repair, and exert a bactericidal effect. (R) -Ofloxacin has a broad-spectrum antibacterial activity and has inhibitory effects on both Gram-negative and Gram-positive bacteria[1][2].

Product Specifications

CAS Number

[100986-86-5]

Product Name Alternative

Dextrofloxacin

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Antibiotic; Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/_R_-Ofloxacin.html

Purity

99.88

Solubility

DMSO : 2.86 mg/mL (ultrasonic; warming; adjust pH to 2 with 1 M HCl; heat to 60°C)

Smiles

O=C(C(C1=O)=CN2[C@H](C)COC3=C(N4CCN(C)CC4)C(F)=CC1=C23)O

Molecular Formula

C18H20FN3O4

Molecular Weight

361.37

Precautions

H302, H315, H319, H335

References & Citations

[1]Zhang, et al. Stereoselective effects and its potential mechanism of ofloxacin on the growth and development of Rana nigromaculata: mainly liver lipid metabolism. Frontiers of Environmental Science & Engineering 19.4 (2025) : 50.|[2]Nahla N. Salama, et al. Thin-Layer Chromatographic Enantioseparation of Ofloxacin and Zopiclone using Hydroxy-Propyl-BetaCyclodextrin as Chiral Selector and Thermodynamic Studies of Complexation. Journal of Planar Chromatography. 27 (2014) 3, 166-173.