LDH-IN-1
LDH-IN-1 is a novel pyrazole-based inhibitor of human lactate dehydrogenase (LDH) with IC50s of 32 and 27 nM for LDHA and LDHB, respectively.
Product Specifications
CAS Number
[1964515-43-2]
UNSPSC
12352005
Hazard Statement
H302
Target
Lactate Dehydrogenase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/LDH-IN-1.html
Purity
99.84
Solubility
DMSO : 52 mg/mL (ultrasonic)
Smiles
O=S(C1=CC=C(CC2=C(N(C3=NC(C(O)=O)=CS3)N=C2C4=CC=CC(C5=CC=CC=C5)=C4)CC6CC6)C=C1)(N)=O
Molecular Formula
C30H26N4O4S2
Molecular Weight
570.68
Precautions
H302
References & Citations
[1]Rai G, et al. Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH) . J Med Chem. 2017 Nov 22;60 (22) :9184-9204.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
LDHA; LDHB
Available Sizes
Curated Selection
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