BMS-561392 (formate)

BMS-561392 formate is the formate form of BMS-561392 (HY-19667) . BMS-561392 is a TNF alpha-converting enzyme (TACE) inhibitor. BMS-561392 is also an ADAM17 blocker. BMS-561392 can be used for research of inflammatory bowel disease[1][2].

Product Specifications

CAS Number

[2922280-85-9]

Product Name Alternative

DPC 333 (formate)

UNSPSC

12352005

Target

TNF Receptor

Type

Reference compound

Related Pathways

Apoptosis

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/bms-561392-formate.html

Purity

98.69

Solubility

DMSO : ≥ 125 mg/mL

Smiles

OC=O.N[C@]1(C2=CC=C(C=C2)OCC3=CC(C)=NC4=C3C=CC=C4)C(N(CC1)[C@H](CC(C)C)C(NO)=O)=O

Molecular Formula

C28H34N4O6

Molecular Weight

522.59

References & Citations

[1]Kim ML, et al. Effects of TNFalpha-converting enzyme inhibition on amyloid beta production and APP processing in vitro and in vivo. J Neurosci. 2008 Nov 12;28 (46) :12052-61. |[2]Vidal PM, et al. ADAM17 is a survival factor for microglial cells in vitro and in vivo after spinal cord injury in mice. Cell Death Dis. 2013 Dec 12;4 (12) :e954.