Choline tosylate

Choline tosylate is a nucleophilic compound that inhibits phospholipase A2 and phospholipase C. Choline tosylate inhibits tumor growth in mice by inhibiting the formation of diacylglycerol (DAG) [1][2].

Product Specifications

CAS Number

[55357-38-5]

Product Name Alternative

Choline p-toluenesulfonate

UNSPSC

12352200

Hazard Statement

H315, H319, H335

Target

Phospholipase

Type

Biochemical Assay Reagents

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/choline-tosylate.html

Purity

99.95

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC1=CC=C(C=C1)S(=O)(=O)[O-].C[N+](C)(C)CCO

Molecular Formula

C12H21NO4S

Molecular Weight

275.37

Precautions

H315, H319, H335

References & Citations

[1]Yu L, et al. The interaction of phospholipase A2 with phospholipid analogues and inhibitors. J Biol Chem. 1990 Feb 15;265 (5) :2657-64.|[2]Trousil S. Choline Kinase Inhibition as a Treatment Strategy of Cancers with Deregulated Lipid Metabolism. Imperial College London, 2014.