GSK2643943A
GSK2643943A is a deubiquitinating enzyme (DUB) inhibitor targeting USP20. GSK2643943A has affinity with an IC50 of 160 nM for USP20/Ub-Rho. GSK2643943A has anti-tumor efficacy and can be used for the research of oral squamous cell carcinoma (OSCC) [1][2].
Product Specifications
CAS Number
[2449301-27-1]
UNSPSC
12352005
Target
Deubiquitinase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/GSK2643943A.html
Concentration
10mM
Purity
98.79
Solubility
DMSO : ≥ 125 mg/mL
Smiles
FC1=CC=CC(/C=C/C2=CC(NC(N)=C3C#N)=C3C=C2)=C1
Molecular Formula
C17H12FN3
Molecular Weight
277.30
References & Citations
[1]Nishi Kumari, et al. Targeting the Ubiquitin Proteasome System in Cancer. Shahzad, Hafiz Naveed (2018) . Neoplasm Targeting the Ubiquitin Proteasome System in Cancer. , 10.5772/intechopen.69560 (Chapter 8) .|[2]Ruitao Lu, et al. USP18 and USP20 restrict oHSV-1 replication in resistant human oral squamous carcinoma cell line SCC9 and affect the viability of SCC9 cells. Mol Ther Oncolytics. 2021 Nov 11;23:477-487.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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